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I'd have said Bootstrap as it's faster for implementation but I've been messing with tailwind for few weeks and it has great potential.
1 downside I've noticed is the continuous npm build that's required while working on my project
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Yes, but I prefer to used to Bulma CSS as compare to Bootstrap
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Bootstrap is a big love from me, but the problem is that it still looks like... well... Bootstrap. But the v5 uses similar approach as Tailwind does.
Tailwind is nice, but can get messy if you use Tailwind as intended (good luck preventing a class attribute's value going out of the screen boundaries).
PureCSS is a pain in the butt to start from scratch.
So my choice is still Bootstrap :)